产品名称
SORC3 Rabbit Polyclonal Antibody
蛋白名称
VPS10 domain-containing receptor SorCS3
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UPU3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UPU3/entry
Mouse Swissprot No.
Q8VI51
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VI51
免疫原
Synthesized peptide derived from part region of human protein
特异性
SORC3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid pre
组织表达
Highly expressed in brain.
细胞定位
Membrane; Single-pass type I membrane protein.
功能
similarity:Contains 1 PKD domain.,similarity:Contains 6 BNR repeats.,tissue specificity:Highly expressed in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
