产品名称
HO-1 (Mix-mA) Mouse Monoclonal Antibody
别名
Heme oxygenase 1 (HO-1) (EC 1.14.99.3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.39% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3162
Human Swissprot No.
P09601
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P09601/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/15368
Mouse Swissprot No.
P14901
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P14901
Rat Gene Link
https://www.uniprot.org/uniprot/24451
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P06762
免疫原
Synthesized peptide derived from human HO-1
特异性
This antibody detects endogenous levels of HO-1 at Human, Mouse,Rat
稀释度
IF 1:50-200 IHC-p1:50-200 ,WB 1:1000-2000
背景介绍
heme oxygenase 1(HMOX1) Homo sapiens Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008],
组织表达
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
细胞定位
Endoplasmic reticulum membrane ; Single-pass type IV membrane protein ; Cytoplasmic side .
功能
catalytic activity:Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O.,function:Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.,induction:Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA.,similarity:Belongs to the heme oxygenase family.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
