产品名称
TP4A1 Rabbit Polyclonal Antibody
基因名称
PTP4A1 PRL1 PTPCAAX1
蛋白名称
Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q93096
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q93096/entry
Mouse Swissprot No.
Q63739
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q63739
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q78EG7
免疫原
Synthesized peptide derived from part region of human protein
特异性
TP4A1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
protein tyrosine phosphatase type IVA, member 1(PTP4A1) Homo sapiens This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013],
组织表达
Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.
细胞定位
Cell membrane ; Lipid-anchor . Early endosome . Endoplasmic reticulum . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Nucleus . And mitotic spindle. .
功能
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,developmental stage:Expressed in fetal liver.,enzyme regulation:Inhibited by sodium orthovanadate and pentamidine.,function:Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.,induction:Strongly down-regulated upon tetrodotoxin treatment.,PTM:Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.,similarity:Belongs to the protein-tyrosine phosphatase family.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subcellular location:And mitotic spindle.,subunit:Homotrimer. Interacts with ATF5 (By similarity). Interacts with tubulin.,tissue specificity:Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
