产品名称
CARF Rabbit Polyclonal Antibody
蛋白名称
CDKN2A-interacting protein (Collaborator of ARF)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NXV6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NXV6/entry
Mouse Swissprot No.
Q8BI72
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BI72
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5U2X0
免疫原
Synthesized peptide derived from part region of human protein
特异性
CARF Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
组织表达
Ubiquitously expressed.
细胞定位
Nucleus, nucleoplasm .
功能
function:Activates TP53/p53 by CDKN2A-dependent and CDKN2A-independent pathways.,PTM:May be ubiquitinated.,similarity:Belongs to the CARF family.,similarity:Contains 1 DRBM (double-stranded RNA-binding) domain.,subunit:Interacts with CDKN2A/p14ARF, TP53/p53 and MDM2.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
