产品名称
JAG2 Rabbit Polyclonal Antibody
蛋白名称
Protein jagged-2 (Jagged2) (hJ2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y219
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y219/entry
Mouse Swissprot No.
Q9QYE5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QYE5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P97607
免疫原
Synthesized peptide derived from part region of human protein
特异性
JAG2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney.
细胞定位
Membrane; Single-pass type I membrane protein.
功能
disease:May be associated with Usher syndrome type IA (USHA1A) which describes a congenital sensory deafness associated with retinitis pigmentosa and feeble-mindedness.,function:Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development.,similarity:Contains 1 DSL domain.,similarity:Contains 1 VWFC domain.,similarity:Contains 16 EGF-like domains.,tissue specificity:Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
