产品名称
AMPKβ1 (Mix-mA) Mouse Monoclonal Antibody
别名
5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.41% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5564
Human Swissprot No.
Q9Y478
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y478/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19079
Mouse Swissprot No.
Q9R078
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R078
Rat Gene Link
https://www.uniprot.org/uniprot/83803
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P80386
免疫原
Synthesized peptide derived from human AMPKβ1
特异性
This antibody detects endogenous levels of AMPKβ1 at Human, Mouse,Rat
稀释度
IHC-p1:50-200 ,WB 1:1000-2000
背景介绍
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided
组织表达
Brain,Lung,Muscle,Platelet,
细胞定位
nucleus,nucleoplasm,cytosol,nucleotide-activated protein kinase complex,
功能
function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adaptor molecule for the catalytic alpha-subunit.,PTM:Phosphorylated.,similarity:Belongs to the 5'-AMP-activated protein kinase beta subunit family.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits. Interacts with FNIP1 and FNIP2.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
