产品名称
TP4A1 Rabbit Polyclonal Antibody
基因名称
PTP4A1 PRL1 PTPCAAX1
蛋白名称
Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q93096
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q93096/entry
Mouse Swissprot No.
Q63739
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q63739
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q78EG7
免疫原
Synthesized peptide derived from part region of human protein
特异性
TP4A1 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
protein tyrosine phosphatase type IVA, member 1(PTP4A1) Homo sapiens This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013],
组织表达
Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.
细胞定位
Cell membrane ; Lipid-anchor . Early endosome . Endoplasmic reticulum . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Nucleus . And mitotic spindle. .
功能
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,developmental stage:Expressed in fetal liver.,enzyme regulation:Inhibited by sodium orthovanadate and pentamidine.,function:Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.,induction:Strongly down-regulated upon tetrodotoxin treatment.,PTM:Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.,similarity:Belongs to the protein-tyrosine phosphatase family.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subcellular location:And mitotic spindle.,subunit:Homotrimer. Interacts with ATF5 (By similarity). Interacts with tubulin.,tissue specificity:Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
