产品名称
DSCAM Rabbit Polyclonal Antibody
蛋白名称
Down syndrome cell adhesion molecule (CHD2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O60469
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60469/entry
Mouse Swissprot No.
Q9ERC8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9ERC8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8VHZ8
免疫原
Synthesized peptide derived from part region of human protein
特异性
DSCAM Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012],
组织表达
Primarily expressed in brain.
细胞定位
[Isoform Short]: Secreted .; [Isoform Long]: Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . Cell projection, growth cone . Cell junction, synapse . Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. .
功能
function:Cell adhesion molecule that can mediate cation-independent homophilic binding activity. Could be involved in nervous system development.,similarity:Contains 10 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 6 fibronectin type-III domains.,tissue specificity:Primarily expressed in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
