产品名称
AMPKβ2 (Mix-mA) Mouse Monoclonal Antibody
别名
5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.42% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5565
Human Swissprot No.
O43741
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43741/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/108097
Mouse Swissprot No.
Q6PAM0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PAM0
Rat Gene Link
https://www.uniprot.org/uniprot/64562
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QZH4
免疫原
Synthesized peptide derived from human AMPKβ2
特异性
This antibody detects endogenous levels of AMPKβ2 at Human, Mouse,Rat
稀释度
IHC-p1:50-200 ,WB 1:1000-2000
背景介绍
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],
细胞定位
nucleoplasm,cytosol,nucleotide-activated protein kinase complex,
功能
function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adapter molecule for the catalytic alpha-subunit.,PTM:Phosphorylated when associated with the catalytic subunit.,similarity:Belongs to the 5'-AMP-activated protein kinase beta subunit family.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
