产品名称
GPC1 Rabbit Polyclonal Antibody
蛋白名称
Glypican-1 [Cleaved into: Secreted glypican-1]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P35052
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P35052/entry
Mouse Swissprot No.
Q9QZF2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QZF2
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P35053
免疫原
Synthesized peptide derived from part region of human protein
特异性
GPC1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008],
组织表达
Brain,Colon,Lung fibroblast,Salivary gland,
细胞定位
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP amyloid-beta peptides in lipid rafts in Alzheimer disease brains.; [Secreted glypican-1]: Secreted, extracellular space.
功能
function:Cell surface proteoglycan that bears heparan sulfate.,PTM:This cell-associated glypican is further processed to give rise to a medium-released species.,similarity:Belongs to the glypican family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
