产品名称
FHL2 Rabbit Polyclonal Antibody
蛋白名称
Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q14192
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14192/entry
Mouse Swissprot No.
O70433
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70433
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O35115
免疫原
Synthesized peptide derived from part region of human protein
特异性
FHL2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016],
组织表达
Expressed in skeletal muscle and heart.
细胞定位
Cytoplasm . Nucleus . Cytoplasm, myofibril, sarcomere, Z line .
功能
domain:The third LIM zinc-binding mediates interaction with E4F1.,function:May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 3 LIM zinc-binding domains.,similarity:Contains 4 LIM zinc-binding domains.,subunit:Interacts with ZNF638 and TTN/titin. Interacts with E4F1.,tissue specificity:Expressed in skeletal muscle and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
