产品名称
MFGM Rabbit Polyclonal Antibody
蛋白名称
Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q08431
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q08431/entry
Mouse Swissprot No.
P21956
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P21956
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P70490
免疫原
Synthesized peptide derived from part region of human protein
特异性
MFGM Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],
组织表达
Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.
细胞定位
Membrane ; Peripheral membrane protein . Secreted . Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Peripheral membrane protein . Located in the acrosomal region of zona-pellucida bound sperm. .
功能
function:Medin is the main constituent of aortic medial amyloid.,function:Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.,PTM:Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 F5/8 type C domain.,similarity:Contains 2 F5/8 type C domains.,similarity:Contains 3 F5/8 type C domains.,tissue specificity:Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
