产品名称
LY96 Rabbit Polyclonal Antibody
蛋白名称
Lymphocyte antigen 96 (Ly-96) (ESOP-1) (Protein MD-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y6Y9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y6Y9/entry
Mouse Swissprot No.
Q9JHF9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JHF9
免疫原
Synthesized peptide derived from part region of human protein
特异性
LY96 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010],
细胞定位
Secreted, extracellular space . Secreted . Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581). .
信号通路
Toll_Like;Pathogenic Escherichia coli infection;
功能
function:Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.,PTM:N-glycosylated; high-mannose.,subunit:Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binds to the extracellular domains of TLR2 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
