产品名称
IκB β (3E4) Mouse Monoclonal Antibody
别名
NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.45% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4793
Human Swissprot No.
Q15653
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15653/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/18036
Mouse Swissprot No.
Q60778
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60778
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JIA3
免疫原
Synthesized peptide derived from human IκB β
特异性
This antibody detects endogenous levels of IκB β at Human, Mouse,Rat
稀释度
IHC-p1:50-200 ,WB 1:1000-2000
背景介绍
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011],
组织表达
Expressed in all tissues examined.
细胞定位
Cytoplasm . Nucleus .
功能
function:Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.,PTM:Phosphorylated; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.,similarity:Belongs to the NF-kappa-B inhibitor family.,similarity:Contains 6 ANK repeats.,subunit:Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2.,tissue specificity:Expressed in all tissues examined.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
