产品名称
GELS Rabbit Polyclonal Antibody
蛋白名称
Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P06396
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P06396/entry
Mouse Swissprot No.
P13020
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P13020
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q68FP1
免疫原
Synthesized peptide derived from part region of human protein
特异性
GELS Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
细胞定位
[Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 1]: Secreted.
信号通路
Fc gamma R-mediated phagocytosis;Regulates Actin and Cytoskeleton;
功能
disease:Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.,function:Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.,online information:Gelsolin entry,PTM:Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.,similarity:Belongs to the villin/gelsolin family.,similarity:Contains 6 gelsolin-like repeats.,subunit:Binds to actin and to fibronectin.,tissue specificity:Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
