产品名称
CATS Rabbit Polyclonal Antibody
蛋白名称
Cathepsin S (EC 3.4.22.27)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P25774
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P25774/entry
Mouse Swissprot No.
O70370
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70370
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q02765
免疫原
Synthesized peptide derived from part region of human protein
特异性
CATS Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010],
组织表达
Alveolar macrophage,Pancreas,Testis,
细胞定位
Lysosome . Secreted . Cytoplasmic vesicle, phagosome .
信号通路
Lysosome;Antigen processing and presentation;
功能
catalytic activity:Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.,function:Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.,similarity:Belongs to the peptidase C1 family.,subunit:Monomer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
