产品名称
THOP1 Rabbit Polyclonal Antibody
蛋白名称
Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P52888
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P52888/entry
Mouse Swissprot No.
Q8C1A5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C1A5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P24155
免疫原
Synthesized peptide derived from part region of human protein
特异性
THOP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015],
组织表达
Brain,Lung,Placenta,Uterus,
信号通路
Renin-angiotensin system;
功能
catalytic activity:Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Binds 1 zinc ion.,function:Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.,similarity:Belongs to the peptidase M3 family.,subunit:Monomer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
