产品名称
SYGP1 Rabbit Polyclonal Antibody
蛋白名称
Ras GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96PV0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96PV0/entry
Mouse Swissprot No.
F6SEU4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/F6SEU4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9QUH6
免疫原
Synthesized peptide derived from part region of human protein
特异性
SYGP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. The encoded protein is phosphorylated by calmodulin-dependent protein kinase II and dephosphorylated by NMDA receptor activation. Defects in this gene are a cause of mental retardation autosomal dominant type 5 (MRD5). [provided by RefSeq, Dec 2009],
细胞定位
cytoplasm,cytosol,postsynaptic density,intrinsic component of the cytoplasmic side of the plasma membrane,dendritic shaft,
功能
alternative products:Additional isoforms seem to exist,caution:It is uncertain whether Met-1 or Met-16 is the initiator methionine.,disease:Defects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5) [MIM:612621]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD5 patients show global developmental delay with delayed motor development, hypotonia, moderate-to-severe mental retardation, and severe language impairment.,function:Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.,PTM:Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,subunit:Interacts CAMK2A and CAMK2B (By similarity). Interacts with MPDZ.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
