产品名称
THOP1 Rabbit Polyclonal Antibody
蛋白名称
Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P52888
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P52888/entry
Mouse Swissprot No.
Q8C1A5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C1A5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P24155
免疫原
Synthesized peptide derived from part region of human protein
特异性
THOP1 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015],
组织表达
Brain,Lung,Placenta,Uterus,
信号通路
Renin-angiotensin system;
功能
catalytic activity:Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Binds 1 zinc ion.,function:Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.,similarity:Belongs to the peptidase M3 family.,subunit:Monomer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
