产品名称
MEP1B Rabbit Polyclonal Antibody
蛋白名称
Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta) (PABA peptide hydrolase) (PPH beta)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q16820
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q16820/entry
Mouse Swissprot No.
Q61847
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61847
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P28826
免疫原
Synthesized peptide derived from part region of human protein
特异性
MEP1B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011],
组织表达
The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.
细胞定位
Cell membrane ; Single-pass type I membrane protein. Secreted . Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17. .
功能
catalytic activity:Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the peptidase M12A family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 MAM domain.,similarity:Contains 1 MATH domain.,subunit:Homotetramer of alpha or beta subunits; heterotetramer of two alpha and two beta subunits are formed by non-covalent association of two disulfide-linked heterodimers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
