产品名称
FKBP8 Rabbit Polyclonal Antibody
蛋白名称
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q14318
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14318/entry
Mouse Swissprot No.
O35465
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35465
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q3B7U9
免疫原
Synthesized peptide derived from part region of human protein
特异性
FKBP8 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed. Highest levels seen in the brain. Highly abundant in the retina.
细胞定位
Mitochondrion . Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side .; [Isoform 1]: Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side .; [Isoform 3]: Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side .
功能
catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,caution:It is uncertain whether Met-1 or Met-58 is the initiator.,cofactor:Calcium.,function:Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.,miscellaneous:Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form.,sequence caution:The first part of the cDNA maps to the same locus, but in opposite orientation.,similarity:Contains 1 PPIase FKBP-type domain.,similarity:Contains 3 TPR repeats.,subunit:Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A.,tissue specificity:Widely expressed. Highest levels seen in the brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
