产品名称
SYGP1 Rabbit Polyclonal Antibody
蛋白名称
Ras GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96PV0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96PV0/entry
Mouse Swissprot No.
F6SEU4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/F6SEU4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9QUH6
免疫原
Synthesized peptide derived from part region of human protein
特异性
SYGP1 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. The encoded protein is phosphorylated by calmodulin-dependent protein kinase II and dephosphorylated by NMDA receptor activation. Defects in this gene are a cause of mental retardation autosomal dominant type 5 (MRD5). [provided by RefSeq, Dec 2009],
细胞定位
cytoplasm,cytosol,postsynaptic density,intrinsic component of the cytoplasmic side of the plasma membrane,dendritic shaft,
功能
alternative products:Additional isoforms seem to exist,caution:It is uncertain whether Met-1 or Met-16 is the initiator methionine.,disease:Defects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5) [MIM:612621]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD5 patients show global developmental delay with delayed motor development, hypotonia, moderate-to-severe mental retardation, and severe language impairment.,function:Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.,PTM:Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,subunit:Interacts CAMK2A and CAMK2B (By similarity). Interacts with MPDZ.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
