产品名称
TM11D Rabbit Polyclonal Antibody
蛋白名称
Transmembrane protease serine 11D (EC 3.4.21.-) (Airway trypsin-like protease) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O60235
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60235/entry
Mouse Swissprot No.
Q8VHK8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VHK8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8VHJ4
免疫原
Synthesized peptide derived from part region of human protein
特异性
TM11D Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008],
组织表达
Located in the cells of the submucosal serous glands of the bronchi and trachea.
细胞定位
Cell membrane; Single-pass type II membrane protein. Activated by cleavage and secreted.; [Transmembrane protease serine 11D catalytic chain]: Secreted. Activated by cleavage and secreted.
功能
catalytic activity:Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.,enzyme regulation:Strongly inhibited by diisopropyl fluorophosphate, leupeptin, antipain, aprotinin, and soybean trypsin inhibitor, but hardly inhibited by secretory leukocyte protease inhibitor at 10 microM.,function:May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 SEA domain.,subcellular location:Activated by cleavage and secreted.,subunit:Monomer.,tissue specificity:Located in the cells of the submucosal serous glands of the bronchi and trachea.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
