产品名称
PRDX5 Rabbit Polyclonal Antibody
蛋白名称
Peroxiredoxin-5, mitochondrial (EC 1.11.1.15) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin reductase)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P30044
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P30044/entry
Mouse Swissprot No.
P99029
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P99029
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9R063
免疫原
Synthesized peptide derived from part region of human protein
特异性
PRDX5 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
细胞定位
[Isoform Mitochondrial]: Mitochondrion .; [Isoform Cytoplasmic+peroxisomal]: Cytoplasm . Peroxisome matrix . Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5. .
功能
catalytic activity:2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.,function:Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.,similarity:Belongs to the peroxiredoxin 2 family.,similarity:Contains 1 thioredoxin domain.,subunit:Monomer.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
