产品名称
LPPR4 Rabbit Polyclonal Antibody
蛋白名称
Lipid phosphate phosphatase-related protein type 4 (EC 3.1.3.4) (Brain-specific phosphatidic acid phosphatase-like protein 1) (Plasticity-related gene 1 protein) (PRG-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q7Z2D5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7Z2D5/entry
Mouse Swissprot No.
Q7TME0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TME0
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q7TMB7
免疫原
Synthesized peptide derived from part region of human protein.AA55-80
特异性
LPPR4 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009],
组织表达
Expressed by glutamatergic neurons (at protein level).
细胞定位
Cell junction, synapse, postsynaptic density membrane ; Multi-pass membrane protein .
功能
catalytic activity:A 3-sn-phosphatidate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.,function:Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.,similarity:Belongs to the PA-phosphatase related phosphoesterase family.,tissue specificity:Specifically expressed in neurons.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
