产品名称
PIGR Rabbit Polyclonal Antibody
蛋白名称
Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P01833
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P01833/entry
Mouse Swissprot No.
O70570
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70570
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P15083
免疫原
Synthesized peptide derived from part region of human protein
特异性
PIGR Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
polymeric immunoglobulin receptor(PIGR) Homo sapiens This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009],
组织表达
Bile,Liver,Milk,Plasma,Saliva,Small intestine,
细胞定位
[Polymeric immunoglobulin receptor]: Cell membrane ; Single-pass type I membrane protein .; [Secretory component]: Secreted .
信号通路
Intestinal immune network for IgA production;
功能
function:This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.,PTM:N-glycosylation is not necessary for Ig binding.,similarity:Contains 5 Ig-like V-type (immunoglobulin-like) domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
