产品名称
FCN2 Rabbit Polyclonal Antibody
蛋白名称
Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q15485
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15485/entry
Mouse Swissprot No.
O70497
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70497
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P57756
免疫原
Synthesized peptide derived from part region of human protein AA range: 41-90
特异性
FCN2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
ficolin 2(FCN2) Homo sapiens The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
组织表达
Expressed by the liver and secreted in plasma.
功能
domain:The fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in carbohydrate binding.,function:May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.,similarity:Belongs to the ficolin lectin family.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 fibrinogen C-terminal domain.,subunit:Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2.,tissue specificity:Expressed by the liver and secreted in plasma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
