产品名称
EXTL3 Rabbit Polyclonal Antibody
基因名称
EXTL3 EXTL1L EXTR1 KIAA0519
蛋白名称
Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O43909
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43909/entry
Mouse Swissprot No.
Q9WVL6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WVL6
免疫原
Synthesized peptide derived from part region of human protein
特异性
EXTL3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. [provided by RefSeq, Nov 2012],
组织表达
Ubiquitous. Expressed in keratinocytes.
细胞定位
Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus .
信号通路
Heparan sulfate biosynthesis;
功能
catalytic activity:UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.,caution:It is uncertain whether Met-1, Met-6 or Met-20 is the initiator.,disease:Candidate gene for the breast cancer locus on chromosome 8p12-p22.,function:Probable glycosyltransferase.,online information:Exostosin-like 3,online information:GlycoGene database,pathway:Glycan metabolism; heparan sulfate biosynthesis.,similarity:Belongs to the glycosyltransferase 47 family.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
