产品名称
TXND5 Rabbit Polyclonal Antibody
基因名称
TXNDC5 TLP46 UNQ364/PRO700
蛋白名称
Thioredoxin domain-containing protein 5 (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8NBS9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NBS9/entry
Mouse Swissprot No.
Q91W90
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91W90
免疫原
Synthesized peptide derived from part region of human protein
特异性
TXND5 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
thioredoxin domain containing 5(TXNDC5) Homo sapiens This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010],
组织表达
Eye,Liver,Lymph,Lymph node,Ovary,PCR rescued clones,Retina,Spleen,Stomach,
细胞定位
Endoplasmic reticulum lumen .
功能
function:Involved in the development of lysosome-related organelles, such as melanosomes and platelet-dense granules.,function:Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.,similarity:Belongs to the Muted family.,similarity:Belongs to the protein disulfide isomerase family.,similarity:Contains 2 thioredoxin domains.,similarity:Contains 3 thioredoxin domains.,subunit:Interacts with pallidin. Interacts with dystrobrevin binding protein 1 and CNO/cappuccino (By similarity). Part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
