产品名称
KIRR2 Rabbit Polyclonal Antibody
基因名称
KIRREL2 NEPH3 UNQ5827/PRO19646
蛋白名称
Kin of IRRE-like protein 2 (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q6UWL6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6UWL6/entry
Mouse Swissprot No.
Q7TSU7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TSU7
免疫原
Synthesized peptide derived from part region of human protein
特异性
KIRR2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016],
组织表达
Highly expressed in beta-cells of the pancreatic islets.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta-catenin. .
功能
similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with C-terminus of NPHS2/podocin.,tissue specificity:Highly expressed in beta-cells of the pancreatic islets.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
