产品名称
BAMBI Rabbit Polyclonal Antibody
蛋白名称
BMP and activin membrane-bound inhibitor homolog (Non-metastatic gene A protein) (Putative transmembrane protein NMA)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q13145
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13145/entry
Mouse Swissprot No.
Q9D0L6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D0L6
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q91XN4
免疫原
Synthesized peptide derived from part region of human protein
特异性
BAMBI Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
BMP and activin membrane bound inhibitor(BAMBI) Homo sapiens This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008],
组织表达
High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.
细胞定位
Membrane ; Single-pass type I membrane protein .
功能
developmental stage:Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.,function:Negatively regulates TGF-beta signaling.,similarity:Belongs to the BAMBI family.,tissue specificity:High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
