产品名称
TXND5 Rabbit Polyclonal Antibody
基因名称
TXNDC5 TLP46 UNQ364/PRO700
蛋白名称
Thioredoxin domain-containing protein 5 (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8NBS9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NBS9/entry
Mouse Swissprot No.
Q91W90
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91W90
免疫原
Synthesized peptide derived from part region of human protein
特异性
TXND5 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
thioredoxin domain containing 5(TXNDC5) Homo sapiens This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010],
组织表达
Eye,Liver,Lymph,Lymph node,Ovary,PCR rescued clones,Retina,Spleen,Stomach,
细胞定位
Endoplasmic reticulum lumen .
功能
function:Involved in the development of lysosome-related organelles, such as melanosomes and platelet-dense granules.,function:Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.,similarity:Belongs to the Muted family.,similarity:Belongs to the protein disulfide isomerase family.,similarity:Contains 2 thioredoxin domains.,similarity:Contains 3 thioredoxin domains.,subunit:Interacts with pallidin. Interacts with dystrobrevin binding protein 1 and CNO/cappuccino (By similarity). Part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
