产品名称
CDO1 Rabbit Polyclonal Antibody
蛋白名称
Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q16878
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q16878/entry
Mouse Swissprot No.
P60334
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P60334
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P21816
免疫原
Synthesized peptide derived from part region of human protein
特异性
CDO1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:L-cysteine + O(2) = 3-sulfinoalanine.,cofactor:Binds 1 iron ion per subunit. Zinc to a much lesser extent.,cofactor:IRON; NAD(P)H.,function:Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.,induction:In hepatoblastoma HepG2 cells, down-regulated by phorbol 12-myristate 13-acetate.,pathway:Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.,PTM:The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.,similarity:Belongs to the cysteine dioxygenase family.,subunit:Monomer.,tissue specificity:Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma HepG2 cells.,
组织表达
Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.
信号通路
Cysteine and methionine metabolism;Taurine and hypotaurine metabolism;
功能
catalytic activity:L-cysteine + O(2) = 3-sulfinoalanine.,cofactor:Binds 1 iron ion per subunit. Zinc to a much lesser extent.,cofactor:IRON; NAD(P)H.,function:Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.,induction:In hepatoblastoma HepG2 cells, down-regulated by phorbol 12-myristate 13-acetate.,pathway:Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.,PTM:The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.,similarity:Belongs to the cysteine dioxygenase family.,subunit:Monomer.,tissue specificity:Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma HepG2 cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
