BD-PE2062-TP63 (5J7) Mouse Monoclonal antibody-现货抗体产品库武汉枢密脑科学技术有限公司

TP63 (5J7) Mouse Monoclonal antibody

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产品基本信息

产品货号

BD-PE2062

产品名称

TP63 (5J7) Mouse Monoclonal antibody

类别

常规抗体

基因名称

TP63

推荐应用

反应种属

Human

存储缓冲液

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% New type preservative N.

免疫原

Full length human recombinant protein of human TP63 (NP_003713) produced in HEK293T cell.

稀释度

WB 1:500, IHC 1:200

预测分子量

76.8kDa

运输及保存条件

-20°C/1 year

宿主

Mouse

同种型

IgG2a

背景介绍

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

期货

2周

纯化

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Immunohistochemical staining of paraffin-embedded Carcinoma of lung tissue using anti-TP63 mouse monoclonal antibody .

Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-TP63 monoclonal antibody .

Western blot analysis of lysates from HEK293T cells transfected with TP63v1 (Right), overexpression plasmid or empty vector plasmid (Left) using anti-TP63 antibodyBD-PE2062 (1:500).

Immunohistochemical staining of paraffin-embedded human lung squamous cell carcinoma tissue using anti-TP63 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120°C for 3 min, BD-PE2062 (1:200)

Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-TP63 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120°C for 3 min, BD-PE2062 (1:200)

Immunohistochemical staining of paraffin-embedded human breast tissue within the normal limits using anti-TP63 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120°C for 3 min, BD-PE2062 (1:200)