产品名称
FCRL4 Rabbit Polyclonal Antibody
基因名称
FCRL4 FCRH4 IFGP2 IRTA1
蛋白名称
Fc receptor-like protein 4 (FcR-like protein 4) (FcRL4) (Fc receptor homolog 4) (FcRH4) (IFGP family protein 2) (hIFGP2) (Immune receptor translocation-associated protein 1) (CD antigen CD307d)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96PJ5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96PJ5/entry
免疫原
Synthesized peptide derived from part region of human protein
特异性
FCRL4 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009],
组织表达
Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
disease:A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.,disease:A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).,function:May function as an inhibitor of the B cell receptor signaling. May function in the B cell-mediated immune response.,PTM:Phosphorylated on cytoplasmic tyrosines upon activation.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Specifically expressed by memory and monocytoid B cells which populate spleen and lymph nodes. Preferentially expressed in memory B cells associated with mucosal tissue (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
