产品名称
MDGA1 Rabbit Polyclonal Antibody
蛋白名称
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8NFP4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NFP4/entry
Mouse Swissprot No.
Q0PMG2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q0PMG2
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P85171
免疫原
Synthesized peptide derived from part region of human protein
特异性
MDGA1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six Ig-like domains, a single fibronectin type III domain, a MAM domain and a C-terminal GPI-anchoring site. Studies in other mammals suggest this protein plays a role in cell adhesion, migration, and axon guidance and, in the developing brain, neuronal migration. In humans, this gene is associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2016],
组织表达
Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues.
细胞定位
Cell membrane ; Lipid-anchor, GPI-anchor . Associated with lipid rafts.
功能
function:Required for radial migration of cortical neurons in the superficial layer of the neocortex.,similarity:Contains 1 fibronectin type-III domain.,similarity:Contains 1 MAM domain.,similarity:Contains 6 Ig-like (immunoglobulin-like) domains.,subcellular location:Associated with lipid rafts.,subunit:Interacts heterophilically through its MAM domain with proteins in axon-rich regions and through its Ig-like domains with proteins in differentiating muscle.,tissue specificity:Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
