产品名称
PROM2 Rabbit Polyclonal Antibody
基因名称
PROM2 PROML2 UNQ2521/PRO6014
蛋白名称
Prominin-2 (PROM-2) (Prominin-like protein 2) (hPROML2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8N271
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N271/entry
Mouse Swissprot No.
Q3UUY6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3UUY6
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8CJ52
免疫原
Synthesized peptide derived from part region of human protein
特异性
PROM2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
组织表达
Present in saliva within small membrane particles (at protein level). Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosal tumor, expressed in spindle-shaped or stellate stromal cells. Expressed in prostate cancer cell lines.
细胞定位
Apical cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein . Cell projection, microvillus membrane ; Multi-pass membrane protein . Cell projection, cilium membrane ; Multi-pass membrane protein . Colocalizes with PROM1. Associates with membrane in a cholesterol-dependent manner. Localizes to the apical and basolateral membranes of epithelial cells (By similarity). .
功能
PTM:Glycosylated.,similarity:Belongs to the prominin family.,subcellular location:Colocalizes with PROM1. Associates with membrane in a cholesterol-dependent manner. Localizes to the apical and basolateral membranes of epithelial cells.,subunit:Binds cholesterol.,tissue specificity:Present in saliva within small membrane particles (at protein level). Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosal tumor, expressed in spindle-shaped or stellate stromal cells. Expressed in prostate cancer cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
