产品名称
GPX3 Rabbit Polyclonal Antibody
蛋白名称
Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P22352
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P22352/entry
Mouse Swissprot No.
P46412
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P46412
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P23764
免疫原
Synthesized peptide derived from part region of human protein
特异性
GPX3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designa
信号通路
Glutathione metabolism;Arachidonic acid metabolism;
功能
catalytic activity:2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.,function:Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.,online information:Glutathione peroxidase entry,PTM:The N-terminus is blocked.,similarity:Belongs to the glutathione peroxidase family.,subunit:Homotetramer.,tissue specificity:Secreted in plasma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
