产品名称
PTPRG Rabbit Polyclonal Antibody
蛋白名称
Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P23470
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P23470/entry
Mouse Swissprot No.
Q05909
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q05909
免疫原
Synthesized peptide derived from part region of human protein
特异性
PTPRG Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008],
组织表达
Found in a variety of tissues.
细胞定位
Membrane ; Single-pass type I membrane protein .
功能
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.,similarity:Contains 1 alpha-carbonic anhydrase domain.,similarity:Contains 1 fibronectin type-III domain.,similarity:Contains 2 tyrosine-protein phosphatase domains.,tissue specificity:Found in a variety of tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
