产品名称
RALA Rabbit Polyclonal Antibody
蛋白名称
Ras-related protein Ral-A
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P11233
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P11233/entry
Mouse Swissprot No.
P63321
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P63321
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P63322
免疫原
Synthesized peptide derived from part region of human protein
特异性
RALA Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
RAS like proto-oncogene A(RALA) Homo sapiens The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane ; Lipid-anchor ; Cytoplasmic side. Cleavage furrow . Midbody, Midbody ring . Mitochondrion . Predominantly at the cell surface in the absence of LPA. In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicles (PubMed:19306925). May colocalize with CNTRL/centriolin at the midbody ring (PubMed:16213214). However, localization at the midbody at late cytokinesis was not confirmed (PubMed:18756269). Relocalizes to the mitochondrion during mitosis where it regulates mitochondrial fission (PubMed:21822277). .
信号通路
Pathways in cancer;Pancreatic cancer;
功能
similarity:Belongs to the small GTPase superfamily. Ras family.,subunit:Interacts with RALBP1 via its effector domain. Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have overlapping binding sites and compete for RALA binding. Interacts with Clostridium exoenzyme C3. Interacts with RALGPS1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
