产品名称
DLL1 Rabbit Polyclonal Antibody
蛋白名称
Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O00548
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00548/entry
Mouse Swissprot No.
Q61483
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61483
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P97677
免疫原
Synthesized peptide derived from part region of human protein
特异性
DLL1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008],
组织表达
Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.
细胞定位
Apical cell membrane ; Single-pass type I membrane protein . Cell junction, adherens junction . Membrane raft . Distributed around adherens junction in the apical endfeet through interactions with MAGI1. .
功能
function:Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.,PTM:Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.,similarity:Contains 1 DSL domain.,similarity:Contains 8 EGF-like domains.,subunit:Interacts with Notch receptors.,tissue specificity:Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
