产品名称
CHLE Rabbit Polyclonal Antibody
蛋白名称
Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P06276
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P06276/entry
Mouse Swissprot No.
Q03311
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q03311
免疫原
Synthesized peptide derived from part region of human protein
特异性
CHLE Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016],
组织表达
Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
功能
catalytic activity:An acylcholine + H(2)O = choline + a carboxylate.,disease:Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.,miscellaneous:Cholinesterase is highly reactive with organophosphate esters.,similarity:Belongs to the type-B carboxylesterase/lipase family.,subunit:Homotetramer. The tetramer is composed of two dimers. The two subunits in a dimer are linked by a disulfide bond.,tissue specificity:Present in most cells except erythrocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
