BD-PE1727

PTPN11 (SHP2) (4Z12) Mouse Monoclonal antibody

常规抗体

SHP2

WB

Human,Mouse,Rat

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% New type preservative N.

Full length human recombinant protein of human PTPN11(NP_002825) produced in HEK293T cell.

WB 1:1000, FCM 1:100

67.8kDa

-20°C/1 year

Mouse

IgG1

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq]

现货

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)