产品名称
OPT Rabbit Polyclonal Antibody
蛋白名称
Opticin (Oculoglycan)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UBM4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UBM4/entry
Mouse Swissprot No.
Q920A0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q920A0
免疫原
Synthesized peptide derived from part region of human protein
特异性
OPT Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq, Jul 2008],
组织表达
Expressed in cartilage and synovial membranes (at protein level) (PubMed:18164633, PubMed:23845380). Expressed in the retina, iris, ligament, skin and fetal liver (at protein level) (PubMed:12019215, PubMed:25136834). Expressed in the retinal pigment epithelium (at protein level) (PubMed:25136834). Expressed in synovial fibroblasts and subchondral bone osteoblasts (PubMed:18164633).
细胞定位
Secreted, extracellular space, extracellular matrix .
功能
function:Binds collagen fibrils.,PTM:O-glycosylated.,similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Class III subfamily.,similarity:Contains 7 LRR (leucine-rich) repeats.,tissue specificity:Retina, iris, ligament, skin and fetal liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
