产品名称
FCN1 Rabbit Polyclonal Antibody
蛋白名称
Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O00602
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00602/entry
Mouse Swissprot No.
O70165
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70165
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9WTS8
免疫原
Synthesized peptide derived from part region of human protein
特异性
FCN1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
ficolin 1(FCN1) Homo sapiens The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008],
组织表达
Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes.
细胞定位
Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side . Found on the monocyte and granulocyte surface (PubMed:20400674).
功能
function:Involved in serum exerting lectin activity. Binds GlcNAc.,similarity:Belongs to the ficolin lectin family.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 fibrinogen C-terminal domain.,subcellular location:Found on the monocyte surface.,subunit:Homopolymer. Interacts with elastin.,tissue specificity:Peripheral blood leukocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes and granulocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
