产品名称
PAX7 Rabbit Polyclonal Antibody
蛋白名称
Paired box protein Pax-7 (HuP1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P23759
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P23759/entry
Mouse Swissprot No.
P47239
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P47239
免疫原
Synthesized peptide derived from part region of human protein
特异性
PAX7 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008],
功能
disease:A chromosomal aberration involving PAX7 is a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator.,function:Probable transcription factor. May have a role in myogenesis.,similarity:Belongs to the paired homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 paired domain.,subunit:Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
