产品名称
VCC1 Rabbit Polyclonal Antibody
基因名称
CXCL17 VCC1 UNQ473/PRO842
蛋白名称
VEGF co-regulated chemokine 1 (C-X-C motif chemokine 17) (Dendritic cell and monocyte chemokine-like protein) (DMC)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q6UXB2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6UXB2/entry
Mouse Swissprot No.
Q5UW37
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q5UW37
免疫原
Synthesized peptide derived from part region of human protein AA range: 1-50
特异性
VCC1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
C-X-C motif chemokine ligand 17(CXCL17) Homo sapiens The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015],
组织表达
Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.
功能
developmental stage:Detected in fetal lung.,function:Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections.,induction:Found to be up-regulated in duodenal mucosa during acute cholera.,online information:CXCL17 entry,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,tissue specificity:Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
