产品名称
HRG Rabbit Polyclonal Antibody
蛋白名称
Histidine-rich glycoprotein (Histidine-proline-rich glycoprotein) (HPRG)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P04196
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P04196/entry
Mouse Swissprot No.
Q9ESB3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9ESB3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q99PS8
免疫原
Synthesized peptide derived from part region of human protein
特异性
HRG Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014],
组织表达
Expressed in macrophages and in malignant cells. Expressed by the liver and secreted in plasma (at protein level).
功能
domain:In addition to having a high His and Pro content, this protein has many internal repeats. 12 tandem repetitions of a 5-residue sequence (GHHPH, consensus) form a histidine-rich region.,function:The physiological function is not yet known. It binds heme, dyes and divalent metal ions. It can inhibit rosette formation and is known to interact with heparin, thrombospondin, and the lysine-binding site of plasminogen. On the basis of its homology with HMW kininogen, the His-rich region of this protein may mediate the contact activation phase of intrinsic blood coagulation cascade.,similarity:Contains 2 cystatin domains.,tissue specificity:Expressed by the liver and secreted in plasma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
