产品名称
IL21R Rabbit Polyclonal Antibody
基因名称
IL21R NILR UNQ3121/PRO10273
蛋白名称
Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Novel interleukin receptor) (CD antigen CD360)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9HBE5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HBE5/entry
Mouse Swissprot No.
Q9JHX3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JHX3
免疫原
Synthesized peptide derived from part region of human protein
特异性
IL21R Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010],
组织表达
Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
细胞定位
Membrane; Single-pass type I membrane protein.
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;
功能
domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:This is a receptor for interleukin-21.,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily.,similarity:Contains 1 fibronectin type-III domain.,subunit:Heterodimer with the common gamma chain. Associates with JAK1.,tissue specificity:Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
