产品名称
JAK1 (3F12） Mouse Monoclonal Antibody
别名
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.78% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3716
Human Swissprot No.
P23458
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P23458/entry
Mouse Swissprot No.
P52332
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P52332
免疫原
Synthesized peptide derived from human JAK1
特异性
This antibody detects endogenous levels of JAK1 at Human, Mouse,Rat
稀释度
IHC-p1:50-200 ,WB 1:200-1000
背景介绍
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
组织表达
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
细胞定位
Endomembrane system; Peripheral membrane protein. Wholly intracellular, possibly membrane associated.
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subcellular location:Wholly intracellular, possibly membrane associated.,subunit:Interacts with IL31RA, JAKMIP1 and SHB.,tissue specificity:Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
