产品名称
IL18 Rabbit Polyclonal Antibody
蛋白名称
Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q14116
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14116/entry
Mouse Swissprot No.
P70380
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70380
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P97636
免疫原
Synthesized peptide derived from part region of human protein
特异性
IL18 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011],
组织表达
Liver,Peripheral blood,Urinary bladder,
细胞定位
Cytoplasm . Secreted . The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). .
信号通路
Cytokine-cytokine receptor interaction;NOD-like receptor;Cytosolic DNA-sensing pathway;
功能
function:Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.,online information:Interleukin-1 entry,similarity:Belongs to the IL-1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
